国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home>(Research) Service>Transcriptome & Epigenome Sequencing>Epigenomics>Whole Genome Bisulfite Sequencing

Whole Genome Bisulfite Sequencing

DNA methylation is essential for life activities and is one of the approaches of gene regulation。For instance, the methylation of CpG island located in promoter and first exon region could inhibit gene expression. Moreover, it plays an important role in tumor research, chromatin remodeling, genetic imprinting, disease research, embryonic development, and epigenetic heterogeneity so on.


Project Advice

The main idea of whole genome bisulfite sequencing (WGBS) research is about difference comparison, commonly, case vs control. After the genomic DNA was treated with bisulfite, the unmethylated C base was transformed into U base, while the methylated C base cannot be changed. After PCR amplification, the U base converts into T, which is different from the C base with methylation modification. WGBS can accurately obtain whole genome methylation profile in single base precision. It is highly recommended that 3-6 biological repeats should be set up to reduce the intra group error and enhance the reliability of the results.


                                   

主站蜘蛛池模板: 定日县| 梨树县| 新竹县| 旬邑县| 开封市| 新安县| 永胜县| 太白县| 桓台县| 凤城市| 当涂县| 庆元县| 山东| 句容市| 黄平县| 儋州市| 武安市| 定南县| 弥渡县| 石嘴山市| 台江县| 南华县| 内丘县| 历史| 江安县| 驻马店市| 曲阳县| 常山县| 班玛县| 阳江市| 黄龙县| 含山县| 汉中市| 仁寿县| 平乐县| 东方市| 海门市| 麻阳| 江油市| 黔南| 丹阳市|