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Indirectly stimulation of DCs by Ganoderma atrum polysaccharide in intestinal-like Caco-2/DCs co-culture model based on RNA-seq

2020-03-27

Abstract

Our  previous study has demonstrated that Ganoderma atrum polysaccharide  (PSG-1) activated the immune response of dendritic cells (DCs) by direct  contacting with surface receptors. However, as a kind of macromolecule  compound, PSG-1 cannot directly stimulate DCs via passing through the  intestine epithelial cells. To investigate the role of PSG-1 in the  interaction between the intestinal epithelium and its internal immune  cells, the intestinal-like Caco-2/DCs co-culture model was established,  then all transcripts of DCs with or without treatment of PSG-1 were  globally screened by RNA-seq. According to the RNA-seq analysis,  cytokine receptor interaction, NF-κB and MAPK signaling pathway were  three important signal pathways annotate to the environmental  information processing. Moreover, cytokine and related proteins  expression were in DCs indirectly stimulated by PSG-1 were raised. These  above findings indicated that PSG-1 indirectly affected the immune  function of DCs in intestinal-like Caco-2/DCs co-culture model, in which  NF-κB and MAPK pathway played essential roles.


Text link:

https://www.sciencedirect.com/science/article/pii/S1756464620300748?via%3Dihub

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