国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home> Market activity > Achievements > article shows > article details

Indirectly stimulation of DCs by Ganoderma atrum polysaccharide in intestinal-like Caco-2/DCs co-culture model based on RNA-seq

2020-03-27

Abstract

Our  previous study has demonstrated that Ganoderma atrum polysaccharide  (PSG-1) activated the immune response of dendritic cells (DCs) by direct  contacting with surface receptors. However, as a kind of macromolecule  compound, PSG-1 cannot directly stimulate DCs via passing through the  intestine epithelial cells. To investigate the role of PSG-1 in the  interaction between the intestinal epithelium and its internal immune  cells, the intestinal-like Caco-2/DCs co-culture model was established,  then all transcripts of DCs with or without treatment of PSG-1 were  globally screened by RNA-seq. According to the RNA-seq analysis,  cytokine receptor interaction, NF-κB and MAPK signaling pathway were  three important signal pathways annotate to the environmental  information processing. Moreover, cytokine and related proteins  expression were in DCs indirectly stimulated by PSG-1 were raised. These  above findings indicated that PSG-1 indirectly affected the immune  function of DCs in intestinal-like Caco-2/DCs co-culture model, in which  NF-κB and MAPK pathway played essential roles.


Text link:

https://www.sciencedirect.com/science/article/pii/S1756464620300748?via%3Dihub

主站蜘蛛池模板: 庆安县| 榕江县| 垦利县| 杭锦后旗| 塔城市| 康平县| 苏尼特右旗| 孝昌县| 绥滨县| 扎鲁特旗| 东丽区| 涞水县| 公安县| 涟源市| 榆中县| 祥云县| 佛坪县| 宁安市| 葵青区| 禹州市| 桐庐县| 乌什县| 洞口县| 花莲市| 壤塘县| 江达县| 韩城市| 百色市| 开封市| 临邑县| 谷城县| 岫岩| 阜城县| 吉林市| 龙泉市| 集贤县| 盱眙县| 新乡市| 什邡市| 建德市| 湖北省|