2018-09-20
Abstract
Tibial dyschondroplasia (TD) is a common skeletal problem of avian species. The cause and etiology of this disorder is still not clear. The intestinal bacterial community is a complex ecosystem and plays very important role in healthy life of human and animals. Many researchers have made the connection between diseases and alteration of gut microbiota. However, little is know about the role of gut microbiota in TD. The objective of this study was to explore the diversity and composition of small and large intestinal bacterial communities of TD chickens. The intestinal contests were collected from healthy and TD chickens at day 18 of the trail. The V3-V4 region of 16S rDNA was ampli?ed and sequenced by high-throughput sequencing. Our results indicated that healthy chickens had higher abundance and diversity of gut microbiota than TD chickens but there was no signi?cant di?erence (P > 0.05) among the gut microbiota of small and large intestine. However, the com- position of bacterial communities were signi?cantly di?erent (P < 0.05) between healthy and TD chickens. The occurrence of gut pathogens associated with immunity and in?ammation were much higher in the intestinal contests of TD chickens as compared to healthy ones. In summary, our results showed an interesting di?erence of gut microbiota between healthy and TD chickens, which provided a new thought about the pathogenesis of TD.
Text link
https://www.sciencedirect.com/science/article/pii/S0882401018301979
