国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home> Market activity > Achievements > article shows > article details

A transcriptomic comparison of theca and granulosa cells in chicken and cattle follicles reveals ESR2 as a potential regulator of CYP19A1 expression in the theca cells of chicken follicles

2018-08-07

圖片1.png


Abstract


Previous studies have shown that theca and granulosa cell layers in follicles do not play the same roles in mammals and birds, especially regarding the synthesis of estrogen. The functions of these two cell types have been well characterized in cattle, but they remain unclear in chickens. To clarify this issue, a comparison of small yellow follicles (SYFs) in chickens and cattle at different follicular development stages was done by weighted gene co-expression network analysis (WGCNA). The modules obtained from WGCNA were used for further identification of the key genes associated with CYP19A1 expression. Module preservation analysis showed high similarity between cow_D (the follicular phase before the LH surge) and chicken_SYF (small yellow follicle between 6 and 8?mm in diameter) datasets, and 10 top hub genes highly associated with CYP19A1 expression in chicken SYFs were identified in each module. A comparison of the transcriptomes of theca and granulosa cells (TCs and GCs) between chicken SYFs and cattle follicles at the differentiation stage, as well as the aforementioned hub genes, revealed that ESR2 is a potential regulator of CYP19A1expression in the theca cells of chicken SYFs. Furthermore, 197 cell-specific (179 in theca and 18 in granulosa) and 235 cell-biased expressed genes (196 in theca and 39 in granulosa) in chicken small yellow follicles were also identified by transcriptomic comparison of theca and granulosa cells.


Keywords 


Chicken Theca Granulosa WGCNA CYP19A1 ESR2


link text 


https://www.sciencedirect.com/science/article/pii/S1744117X18300170?via%3Dihub=

主站蜘蛛池模板: 屏边| 唐山市| 甘孜县| 惠水县| 蒙自县| 新兴县| 全南县| 柘城县| 保靖县| 鹤岗市| 新闻| 永修县| 巴南区| 嘉禾县| 望都县| 内江市| 松溪县| 林周县| 同江市| 永善县| 宝兴县| 泉州市| 南投市| 珠海市| 河北区| 永寿县| 理塘县| 醴陵市| 鸡西市| 察隅县| 濮阳市| 日照市| 玉田县| 许昌市| 大宁县| 山阴县| 临城县| 桦南县| 江北区| 龙游县| 克什克腾旗|