国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home> Market activity > Achievements > article shows > article details

Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy

2018-06-26

Abstract

Aims

Dilated cardiomyopathy (DCM) induced chronic heart failure is a life-threatening disease worldwide. Long non-coding RNAs (lncRNAs) are potential new therapeutic targets and may provide new pathophysiological mechanisms for development of DCM.


Methods and results


Microarray assays in 14 DCM and 10 control human heart samples identified 313 significantly differentially expressed lncRNAs. SiRNAs were used to explore the potential function of specific lncRNAs (RP11-544D21.2 and XLOC_014288) in human cardiac myocytes, human cardiac fibroblasts and human cardiac microvascular endothelial cells, respectively. RNA-seq and pathway analyses revealed the function of lncRNA RP11-544D21.2 and XLOC_014288 in three heart cells. Furthermore, impaired tube formation and migration were observed in si-RP11-544D21.2-treated endothelial cells. Moreover, TAF10 was predicted and verified to be one of the causes of some up-regulated lncRNAs. Then, we found that the left ventricular ejection fraction correlated with these changed lncRNAs.


Conclusions

This study provides a comparison of human cardiac lncRNA profiles in control and DCM. It illustrates the function and complex roles of the differentially expressed lncRNAs in different cell types in the heart, which may lead to new insights into the mechanisms and treatment strategies for DCM in the future.


link text : https://academic.oup.com/cardiovascres/article-abstract/114/5/747/4819252?redirectedFrom=fulltext


主站蜘蛛池模板: 南皮县| 寿宁县| 精河县| 景宁| 车险| 南岸区| 高要市| 孟津县| 如东县| 河津市| 瑞安市| 东莞市| 和龙市| 上思县| 道孚县| 定安县| 万州区| 兴宁市| 原平市| 新化县| 汕头市| 壶关县| 共和县| 安图县| 九龙城区| 峨眉山市| 嫩江县| 涪陵区| 海丰县| 博乐市| 新干县| 同德县| 义乌市| 和平县| 清镇市| 化德县| 芒康县| 楚雄市| 汽车| 金沙县| 隆回县|