国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home> Market activity > Achievements > article shows > article details

Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

2017-03-10


Abstract:

Background:

The gastrointestinal tract is populated by a complex and vast microbial network, with a composition that reflects the relationships of the symbiosis, co-metabolism, and co-evolution of these microorganisms with their host. The mechanism that underlies such interactions between the genetics of the host and gut microbiota remains elusive.

Results:

To understand how genetic variation of the host shapes the gut microbiota and interacts with it to affect the metabolic phenotype of the host, we compared the abundance of microbial taxa and their functional performance between two lines of chickens (fat and lean) that had undergone long-term divergent selection for abdominal fat pad weight, which resulted in a 4.5-fold increase in the fat line compared to the lean line. Our analysis revealed that the proportions of Fusobacteria and Proteobacteria differed significantly between the two lines (8 vs. 18% and 33 vs. 24%, respectively) at the phylum level. Eight bacterial genera and 11 species were also substantially influenced by the host genotype. Differences between the two lines in the frequency of host alleles at loci that influence accumulation of abdominal fat were associated with differences in the abundance and composition of the gut microbiota. Moreover, microbial genome functional analysis showed that the gut microbiota was involved in pathways that are associated with fat metabolism such as lipid and glycan biosynthesis, as well as amino acid and energy metabolism. Interestingly, citrate cycle and peroxisome proliferator activated receptor (PPAR) signaling pathways that play important roles in lipid storage and metabolism were more prevalent in the fat line than in the lean line.

Conclusions:

Our study demonstrates that long-term divergent selection not only alters the composition of the gut microbiota, but also influences its functional performance by enriching its relative abundance in microbial taxa. These results support the hypothesis that the host and gut microbiota interact at the genetic level and that these interactions result in their co-evolution.


主站蜘蛛池模板: 张家界市| 阿巴嘎旗| 筠连县| 侯马市| 株洲市| 南京市| 太湖县| 昆山市| 唐山市| 酒泉市| 呼玛县| 孝感市| 淮滨县| 株洲市| 渝北区| 施秉县| 张掖市| 黎城县| 凤阳县| 登封市| 赤壁市| 隆林| 桃源县| 上虞市| 黄平县| 江西省| 汤原县| 伊宁县| 宣威市| 无极县| 百色市| 文化| 吉安县| 南宁市| 安化县| 冀州市| 土默特左旗| 陵水| 曲松县| 高雄市| 尉氏县|