国产青榴社区91精品,久久成人精品免费播放,久久精品人人做人人试看

Home> Market activity > Achievements > article shows > article details

Divergent selection-induced obesity alters the composition and functional pathways of chicken gut microbiota

2017-03-10


Abstract:

Background:

The gastrointestinal tract is populated by a complex and vast microbial network, with a composition that reflects the relationships of the symbiosis, co-metabolism, and co-evolution of these microorganisms with their host. The mechanism that underlies such interactions between the genetics of the host and gut microbiota remains elusive.

Results:

To understand how genetic variation of the host shapes the gut microbiota and interacts with it to affect the metabolic phenotype of the host, we compared the abundance of microbial taxa and their functional performance between two lines of chickens (fat and lean) that had undergone long-term divergent selection for abdominal fat pad weight, which resulted in a 4.5-fold increase in the fat line compared to the lean line. Our analysis revealed that the proportions of Fusobacteria and Proteobacteria differed significantly between the two lines (8 vs. 18% and 33 vs. 24%, respectively) at the phylum level. Eight bacterial genera and 11 species were also substantially influenced by the host genotype. Differences between the two lines in the frequency of host alleles at loci that influence accumulation of abdominal fat were associated with differences in the abundance and composition of the gut microbiota. Moreover, microbial genome functional analysis showed that the gut microbiota was involved in pathways that are associated with fat metabolism such as lipid and glycan biosynthesis, as well as amino acid and energy metabolism. Interestingly, citrate cycle and peroxisome proliferator activated receptor (PPAR) signaling pathways that play important roles in lipid storage and metabolism were more prevalent in the fat line than in the lean line.

Conclusions:

Our study demonstrates that long-term divergent selection not only alters the composition of the gut microbiota, but also influences its functional performance by enriching its relative abundance in microbial taxa. These results support the hypothesis that the host and gut microbiota interact at the genetic level and that these interactions result in their co-evolution.


主站蜘蛛池模板: 阜康市| 肇东市| 鄂伦春自治旗| 陆川县| 邹城市| 伊通| 乐都县| 四平市| 平阴县| 北川| 临猗县| 田阳县| 民丰县| 巴青县| 江安县| 理塘县| 景泰县| 太谷县| 井研县| 通海县| 贵定县| 唐河县| 礼泉县| 民乐县| 高邑县| 青州市| 藁城市| 手机| 嘉鱼县| 宜章县| 会同县| 奉新县| 湾仔区| 汉阴县| 柞水县| 新龙县| 花垣县| 休宁县| 神农架林区| 太原市| 新邵县|